Annual report pursuant to Section 13 and 15(d)

Selected Quarterly Financial Data (Unaudited) (Details)

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Selected Quarterly Financial Data (Unaudited) (Details) - USD ($)
1 Months Ended 3 Months Ended 12 Months Ended
Aug. 14, 2017
Aug. 31, 2017
Dec. 31, 2017
Sep. 30, 2017
Jun. 30, 2017
Mar. 31, 2017
Dec. 31, 2016
Sep. 30, 2016
Jun. 30, 2016
Mar. 31, 2016
Dec. 31, 2017
Dec. 31, 2016
Dec. 31, 2015
Quarterly Financial Data [Abstract]                          
License and other revenue $ 25,000,000 $ 25,000,000 $ 0 $ 25,000,000 $ 0 $ 0         $ 25,000,000 $ 0 $ 0
Product revenue, net     1,911,000 0 0 0         1,910,403 0 0
Sales force revenue     278,000 0 0 0         278,165 0 0
Grant revenue     45,000 38,000 158,000 384,000         624,569 1,152,987 0
Cost of product sales     636,000 0 0 0         635,648 0 0
Research and development     1,961,000 965,000 494,000 953,000 $ 773,000 $ 4,582,000 $ 2,502,000 $ 2,293,000 4,372,578 10,149,879 6,587,183
General and administrative     3,021,000 2,152,000 1,439,000 1,330,000 1,095,000 1,703,000 1,636,000 2,649,000 7,941,584 7,083,155 4,422,764
Sales and marketing     973,000 0 0 0         973,345 0 0
Change in fair value of warrant liability, unit purchase option liability and investor rights obligation     (28,000) 0 2,000 (4,000) 130,000 (101,000) 91,000 (47,000) (29,624) 72,625 1,313,049
Interest expense, net     31,000 29,000 (26,000) (58,000) (83,000) (104,000) (127,000) (151,000) (24,016) (464,181) (793,205)
Net income (loss)     $ (3,091,000) $ 18,721,000 $ (1,799,000) $ (1,961,000) $ (1,639,000) $ (6,169,000) $ (3,524,000) $ (5,140,000) $ 11,869,823 $ (16,471,603) $ (10,490,103)
Net income (loss) per share of common stock, basic (in dollars per share)     $ (0.11) $ 0.52 $ (0.14) $ (0.19)         $ 0.42 $ (1.87) $ (4.71)
Net income (loss) per share of common stock, diluted (in dollars per share)     $ (0.11) $ 0.52 $ (0.14) $ (0.19)         $ 0.42 $ (1.87) $ (4.71)
Net loss per share of common stock, basic and diluted (in dollars per share)             $ (0.18) $ (0.70) $ (0.41) $ (0.59)