Annual report pursuant to Section 13 and 15(d)

Selected Quarterly Financial Data (Unaudited) (Details)

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Selected Quarterly Financial Data (Unaudited) (Details) - USD ($)
3 Months Ended 12 Months Ended
Dec. 31, 2015
Sep. 30, 2015
Jun. 30, 2015
Mar. 31, 2015
Dec. 31, 2014
Sep. 30, 2014
Jun. 30, 2014
Mar. 31, 2014
Dec. 31, 2015
Dec. 31, 2014
Dec. 31, 2013
Quarterly Financial Data [Abstract]                      
Research and development $ 1,751,000 $ 1,238,000 $ 1,875,000 $ 1,723,000 $ 2,259,000 $ 4,371,000 $ 2,861,000 $ 2,750,000 $ 6,587,183 $ 12,240,535 $ 8,914,084
General and administrative 1,924,000 722,000 1,016,000 761,000 1,575,000 1,627,000 794,000 879,000 4,422,764 4,875,030 4,020,364
Change in fair value of warrant liability, unit purchase option liability and investor rights obligation 185,000 1,465,000 198,000 (535,000) 1,532,000 348,000 386,000   1,313,049 2,266,161 (121,115)
Interest income (expense), net (158,000) (197,000) (219,000) (219,000) (221,000) (190,000) (795,000) 0 (793,205) (1,206,187) 10,555
Net loss (3,648,000) (692,000) (2,912,000) (3,238,000) (2,523,000) (5,840,000) (4,064,000) (3,629,000) (10,490,103) (16,055,591) (13,045,008)
Net loss attributable to common stockholders $ (3,648,000) $ (692,000) $ (2,912,000) $ (3,238,000) $ (2,523,000) $ 6,695,000 $ (4,064,000) $ (3,629,000) $ (10,490,103) $ (3,521,153) $ (13,126,972)
Net loss per share of common stock, basic and diluted $ (0.53) $ (1.06) $ (4.48) $ (4.98) $ (3.88) $ 10.35 $ (6.39) $ (5.71) $ (4.71) $ (5.48) $ (20.72)